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Mol Neurobiol 60(4):19291948 Kaur T et al (2024) Unraveling neuroprotection in Parkinsons disease: Nrf2Keap1 pathways vital role amidst pathogenic pathways

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A first group of studies suggested that mTOR-mediated regulation of autophagy only plays a minor role, at least in skeletal muscle

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Primary endpoints should center on pain and function Knee Injury and Osteoarthritis Outcome Score (KOOS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Patient-Reported Outcome Measurement Information System (PROMIS) scores), structure (MRI evaluation with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) when appropriate), and time to milestones (return to sport)